Death related to neutropenia occurs at approximately what rate?

• A. 0.013%, severe 2.1%
• B. 0.1%, 0.5%
• C. 1%, 5%
• D. 5%, 10%

Answer: (A)

In people treated with clozapine, death from neutropenia is extremely rare, thanks to ongoing blood monitoring and prompt intervention. The best estimates place death from neutropenia at about 0.013%, while the rate of developing severe neutropenia (agrannulocytosis) is around 2.1%. This reflects the idea that many patients may experience significant neutropenia, but fatalities are uncommon due to early detection and management, whereas the condition requiring stopping the drug occurs more frequently than death.