Incidence of clozapine-associated neutropenia is approximately what values?

• A. 0.5%, severe 0.1%
• B. 5%, severe 2%
• C. 2.8%, severe 0.9%
• D. 1%, severe 0.1%

Answer: (C)

Clozapine carries a recognized risk of neutropenia and, more rarely, agranulocytosis, which is why blood monitoring is essential. In large studies, neutropenia occurs in roughly three percent of patients, while the severe form is seen in about one percent. The values around three percent for neutropenia and about one percent for severe neutropenia align with these commonly cited estimates, making them the best match. While exact rates can vary by population and monitoring practices, this pattern reflects the typical risk profile for clozapine.