Which of the following is listed as an anticholinergic medication?

• A. Sertraline
• B. Amitriptyline
• C. Metformin
• D. Lisinopril

Answer: (B)

Anticholinergic medications block acetylcholine at muscarinic receptors, reducing parasympathetic activity. This often leads to dry mouth, constipation, blurred vision, urinary retention, and potential cognitive effects, especially in older adults. Amitriptyline, a tricyclic antidepressant, has strong antimuscarinic (anticholinergic) properties, which is why it is listed as an anticholinergic medication. Sertraline mainly affects serotonin reuptake with only minimal anticholinergic activity. Metformin and lisinopril do not have meaningful anticholinergic effects.